PhD G.V. Buznik¹
Dr.Med. A.O. Pyatibrat²
Dr.Med., Professor P.V. Rodichkin³
Dr.Med., Professor P.D. Shabanov^{1, 4
1}Institute of Experimental Medicine, St. Petersburg
²Nikiforov All-Russian Center of Emergency and Radiation Medicine (ARCERM, EMERCOM of Russia), St. Petersburg
³Herzen State Pedagogical University of Russia, St.Petersburg
⁴S.M. Kirov Military Medical Academy MO RF, St. Petersburg

The study was designed to analyze the bodily homeostasis in extreme situations versus the metabolism controlling gene polymorphism. The study data showed correlations of different gene alleles with adaptability to high physical loads. Subject to a pharmacological analysis under the study were the effects of Metaprot and Citoflavin on the athletes’ functionality rates under extreme physical loads. Metaprot was found to improve the adaptation mechanisms under extreme loads both in the biochemical and organs-specific levels, with significant savings in the performance rehabilitation time. Citoflavin was also tested to be of positive effect on the bodily adaptation mechanisms, particularly in rehabilitation periods; with the rehabilitative effects of Citoflavin found the most expressed in the athletes tested with different combinations of homozygote alleles associated with the lower aerobic productivity rates. The study data and analyses give grounds to conclude that the actual effects of pharmacological agents of nootropic action are largely determined by the anaerobic metabolism controlling gene polymorphism.

Keywords: molecular genetics, endurance, functional reserves, professional selection, extreme physical loads, adaptation, biochemical indicators, pharmacological support.

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